Wonderful news!  Science Foundation Ireland, announces breast cancer research award for €800,000 for Caroline Foundation (TCF)  funded research.

Sincerest congratulations to all at Cancer Clinical Research Trust, Prof John Crown, TCF’s Dr Denis Collins and the team at NICB at DCU!  Yesterday’s news is a deserved recognition of your dedication and commitment to the work of Cancer Research.

Research supported and funded by The Caroline Foundation, in partnership with CCRT, has been granted a Strategic Partnerships Award of €800,000 (€400,000 from Science Foundation Ireland and €400,000 in 50:50 matched funding from Puma Biotechnology, Inc.).  The award will fund a project known as ACORN, trAnslational Cancer research On pan-HER inhibitioN, led by Prof. John Crown (Principal Investigator) and Dr. Denis Collins (Co-Principal Investigator) of DCU.

The Caroline Foundation funds the work of Dr Denis Collins as the holder of one of The Caroline Foundation Fellowships.  See below extract from SCI press release issued after Minister for Further and Higher Education, Research, Innovation and Science, Simon Harris made the announcement:

“ACORN is a partnership between DCU and Puma Biotechnology, Inc., which aims to further investigate the activity of the HER2+ breast cancer drug, neratinib, as well as its potential use in the treatment of other cancer types. The research will investigate whether neratinib works best alone or with other drugs and whether there are markers in patient blood or tumours which can predict whether they will respond to neratinib treatment.

ACORN aims to advance cancer research skills in DCU and bring new findings to clinical trials that will benefit cancer patients in Ireland and globally. Previous research led by Prof. Crown resulted in a clinical trial, Caroline-1, which is working with  patients with advanced HER2+ breast cancer in Saint Vincent’s University Hospital in Dublin. The ongoing Caroline-1 study demonstrates the clinical impact of DCU’s translational research (“bench to bedside”) programme. ACORN will provide the world-class research to support future clinical trials in Ireland.”

For more information see the links below to the SFI, DCU and Silicon Republic websites:




We hope news of this award will gladden the hearts of all of TCF supporters.  It is thanks to your loyalty and generosity over the years that we have been able to financially support this research at its fledging stage when it most needed nurturing.  Thank you.  Should anyone wish to make a donation to continue the work of TheCarolineFoundation/CCRT research please use the DONATE button on our website.